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codV [2017-8-11 16:0:3]
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codV [2017-8-11 16:0:3]

site-specific integrase/recombinase, partitioning of the terminus region after replication
locus
BSU16140
pI
9.31
mw
35.19 kDa
protein length
304 aa Sequence Blast
gene length
912 bp Sequence Blast
function
chromosome partitioning
product
site-specific integrase/recombinase
essential
no
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.3|DNA condensation/ segregation]

    • Gene

    Coordinates
    1,687,187 → 1,688,101

    The protein

    Catalyzed reaction/ biological activity

  • resolution of chromosome dimers by site specific recombination at the dif site (located close to the terminus region on the chromosome)

    • Protein family

  • XerC subfamily (according to Swiss-Prot)

    • Paralogous protein(s)

  • [protein|301568A5255A31538F52C46D7711EDAB2BD9CE90|RipX]

    • Structure

  • [PDB|1A0P] (from ''E. coli'', 39% identity, complex with [protein|301568A5255A31538F52C46D7711EDAB2BD9CE90|RipX]) [Pubmed|9311978]

    • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)
  • assembles on the chromosome at the dif site throughout the cell cycle [Pubmed|21239579]

    • Expression and Regulation

    Operons

    genes
    [gene|B6062575849EA65BB7B44A9723676885799E2759|trmFO]-[gene|89746E312F20C81BE3CFDFCE7D99B01C375C198B|codV]-[gene|F6B748621B312E0B5A0A0782F3944C3E8112D7A8|clpQ]-[gene|2A5A080273CB7698DFABB147F4143E90BBCA3B01|clpY]-[gene|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|codY]
    description
    [Pubmed|22383849]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|7783641], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

    • regulatory mechanism

  • [protein|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|CodY]: repression, [Pubmed|11331605], in [regulon|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|CodY regulon]

    • regulation

  • repressed during growth in the presence of branched chain amino acids ([protein|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|CodY]) [Pubmed|11331605]

    • additional information

  • the intracellular concentration of CodY is about 2.5 myM (according to [PubMed|20408793])
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    Biological materials

    Mutant

  • 1A794 ( ''codV''::''kan''), [Pubmed|10498718], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A794&Search=1A794 BGSC]

    • References

    Reviews

  • 23400100

    • Original publications

  • 10498718,16597952,11208805,11331605,7783641,21239579,9311978